Summary
Overview
Work History
Education
Skills
Phone
Websites
Personal Information
References
Studies Applied For - Degree
Job Applied For - Position
Timeline
Generic
David Gabriel Macheque

David Gabriel Macheque

Marracuene,MPM

Summary

Dynamic Laboratory Advisor with extensive experience at the Ministry of Health, specializing in TB diagnostic technologies and drug susceptibility testing. Proven track record in project coordination and stakeholder engagement, enhancing laboratory quality assurance and training delivery. Adept at critical thinking and problem resolution, driving impactful public health strategies.

Overview

23
23
years of professional experience

Work History

Laboratory Advisor

Ministry of Health
Maputo
01.2020 - Current
  • National Tuberculosis Program Control, , Eduardo Mondlane/Salvador Alende Av
  • Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038
  • Provide technical assistance, design, execute, coordinate and follow-up activities for implementation of new TB diagnostic technologies in the country (Truenat, Xpert MTB/XDR), participate in research projects, provide training and assistance for TB diagnostic technologies available in the country;
  • Coordinate the implementation of technical activities in the laboratory for sample referencing, sample processing trough smear microscopy, GeneXpert MTB/RIF testing, culture, speciation of the strains, Drug Susceptibility Testing (DST) by genotypic (Line Probe Assay) and phenotypic (BACTEC MGIT 960) DST for 1st and 2nd line drugs;
  • Coordinate and participate in technical meetings and routine activities in the NTP;
  • Provide periodic reports on the activities progress, output and outcome measures with local stakeholders, national and international
  • Per-reviewer of the Journal of Tuberculosis Research (JTR)
  • P, O
  • BOX 54821, IRVINE CA 92619-4821, USA
  • Http://www.scirp.org/journal/jtr; mail jtr@scirp.org
  • Per-review of the scientific papers related to TB field for publication purposes in JTR.

Laboratory Advisor

01.2012 - 01.2017
  • The National TB Program and Laboratory Coordinator of the Drug Resistance Survey

Senior Laboratory Specialist

Khalide Azam, East
01.2011 - 01.2017
  • Central and Southern Africa Health Community (ECSA-HC);
  • Address: Plot No
  • 157 Oloirien, Njiro Road, P.O Box 1009, Arusha-Tanzania;
  • Phone number: +258 84 707 1980; E-mail: Kie.azam@live.com
  • Relationship: Khalide Azam was my supervisor from, at National Tuberculosis Reference Laboratory (NTRL) during my trainee at the Lab, later he was my head as I was employed at the NTRL were I was working as technician, coordinator of external quality assessment, mentor of regional laboratory of the country.

Assistant Professor

Alda Ester Chongo, Eduardo Mondlane University, UEM
01.2002 - 01.2015
  • Praça 25 de Junho, Postal Code: 257, Maputo, Mozambique
  • Phone number: +258 82 431 1030; E-mail: aestermz@gmail.com
  • Relationship: Alda Chongo was my professor in the Medical Microbiology, Immunology modules, supervisor of my graduation thesis at Eduardo Mondlane University
  • Ensure the maintenance of mobile laboratories, including electrical stability of Xpert machines to prevent damage;
  • Develop laboratory procedures and ensure the application of the mobile clinics of the survey;
  • Coordinate and organize the activities of the survey in the mobile clinics and National Tuberculosis Reference Laboratory;
  • Ensure the quality and reliability of the data of the survey as described and approved in the study protocol;
  • Ensure the development and availability of training manual and study materials; organize the training for all laboratory personnel in processing of smear microscopy, GeneXpert MTB/RIF, TB culture in solid and liquid medium, processing of the samples by Line Probe Assay (LPA) and Drug Susceptibility Tests (DST);
  • Provide supervision for all laboratory personnel and develop improvements plans to acquire the successful for the survey;
  • Alert the principal investigators and the General Coordinator of the study for any challenges or problem that may affect the integrity and quality of the data;
  • Provide periodic reports on the quality of the laboratory process, output and outcome measures to share with local stakeholders, national and international;
  • Coordinate and manage the visits of several international experts, and implement its recommendations to improve the quality of the data in the survey., europass.cedefop.europa.eu Page 5 / 5

Tuberculosis Control Program Manager

Benedita José, National Public Health, Public
01.2008
  • V.R
  • NAMBURETE, E.I
  • FELICIANO, C.S.; MACHEQUE, D.; HARRISON, L.H.; CAMINERO, J
  • (2016)
  • Detection of KatG and inhA Mutation to Guide Isoniazida and Ethionamide use for Drug-resistant Tuberculosis
  • Int J
  • Tuberc Lung Dis
  • 20(8): 1099-104
  • Doi: 10.5588/ijtld.15.0864;
  • Hamada, at al
  • (2023)
  • Association of diabetes, smoking, and alcohol use with subclinical-to-symptomatic spectrum of tuberculosis in 16 countries: an individual participant data meta-analysis of national tuberculosis prevalence surveys
  • EClinicalMedicine
  • Attended to the XVIth International Congress of Infectious Diseases (16th ICID) in Cape Town, were presented a paper entitled Morphologic Assessment of Cord Factor for Rapid and Presumptive Identification of Mycobacterium tuberculosis Complex;
  • Attended to the 51st World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union), held on 20-24 October, 2020, we presented a paper titled GeneXpert and Culture for all in the Mozambique national TB prevalence survey, ensuring quality of lab procedures and addressing discordant results;
  • Participated in Maputo Tuberculosis Trial Unit project (MaTuTU) for establishment of research unit in Mozambique;
  • Participated in project for Evaluation of a New Urine Test (URI-TB-direct) for Tuberculosis (TB) Diagnosis in Children in Maputo;
  • Participated in Project for a Retrospective Treatment Practices and Outcomes among Persons with Multidrug Resistant Tuberculosis in Mozambique of Centre for Disease Control and Prevention (CDC);
  • Participated in the XV Health Conference of the National Institute of Health under the slogan Research and Innovation in Health for the Development of Mozambique in 2012;
  • Participated in the XIV Health Conference of the National Institute of Health under the slogan Research Institutions Contributing to Health Improvement in Mozambique in 2015;
  • Participated in the Seminar on the Incorporation of New Technologies for the Control of Tuberculosis Organized by the National Institute of Health (INS) in 2014;
  • Attended to the general training for reception and testing of suspected samples of SARS-COV-2, by the National Health Institute (INS);
  • Attended to the general training to the First National Pulmonary Tuberculosis Prevalence Survey in Mozambique (INaTB 2017/2018) of National Tuberculosis Program Control, Ministry of Health;
  • Attended to the “Implementation of Line Probe Assay for detection of resistances to second line anti-tuberculosis drugs and for identification of nontuberculous mycobacteria course” held by Fondazione C
  • San Raffaele del Monte Tabor in the National Tuberculosis Reference Laboratory;
  • Participated in the course of Drugs Susceptibility Testing to Second Line for Mycobacterium tuberculosis held by Fondazione C
  • San Raffaele del Monte Tabor in the National Tuberculosis Reference Laboratory;
  • Trained by the African Centre for Integrated Laboratory in Practical Course on Drug Susceptibility Testing to First Line for Mycobacterium tuberculosis Complex held in ACILT, Johannesburg, South Africa;
  • Participated in the course of Training of Trainers for GeneXpert MTB/RIF by Cepheid and Foundation for Innovative New Diagnostics (FIND);
  • Trained by Foundation for Innovative New Diagnostics (FIND) in Practical Course on Decontamination, Liquid Culture and DST, Rapid Speciation and LPA in the National Tuberculosis Reference Laboratory;
  • Trained in Metrology and Testing / Equipment Management by the National Institute for Standards and Quality (INNOQ);
  • Participated in the Course of Quality Control and Validation of Methods by the National Institute of Health (NIH);
  • Trained by the American Society for Microbiology (ASM) in integrated supervision;
  • Capacitated in Training of the Trainers in competency assessment by the American Society for Microbiology (ASM);
  • Received Certificate of Merit in recognition of his performance, participation and contribution in the process of accreditation of the National Tuberculosis Reference Laboratory under NP ISO 15189 by the Portuguese Accreditation Institute (IPAC
  • National Direction of Public Health, National Tuberculosis Program Control, Ministry of Health, Eduardo Mondlane/Salvador Alende Av
  • Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038, Directorate of Ministry of Health, Mozambique;
  • Address: Eduardo Mondlane/ Salvador Allende Av
  • Nr 1008;
  • Phone number: +258 82 002 5907; E-mail: beneditajose1@gmail.com
  • Relationship: is my currently head at Ministry of Health were I’m working as Senior Laboratory Advisor and study coordination
  • Ivan Manhiça, MD, MSc – Was the National Tuberculosis Control Program Manager at National, Health Directorate of Ministry of Health, Mozambique from, to 2020;
  • Address: Eduardo Mondlane/ Salvador Allende Av
  • Nr 1008;
  • Phone number: +258 82 391 7970; E-mail: ivanmca2004@yahoo.com.br
  • Relationship: Ivan Manhiça was my head at Ministry of Health were I’m working as Laboratory Coordinator of TB Prevalence Survey where I’m involved in the coordination of technical activities and also development of the survey report.

Advisor

Curriculum Vitae
  • The 3rd Drug Resistance Survey (DRS)
  • National Direction of Public Health, National Tuberculosis Program Control, Ministry of Health, Eduardo Mondlane/Salvador Alende Av
  • Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038
  • Manage the team in carrying out technical activities in the laboratory and coordinate tasks for receiving samples, smears for smear microscopy, culture, speciation of strains, Line Probe Assay (LPA) assay of 1st and 2nd line and Susceptibility Tests of 1st and 2nd line drugs (TSA) using phenotypic methods;
  • Coordinate technical meetings in the laboratory and participate in coordination meetings of the Board of the Ministry of Health;
  • Develop laboratory procedures and ensure the application of this documents in all survey sites (field level and central level);
  • Provide supervision for all survey sites and develop improvements plans to acquire the successful for the survey;
  • Alert the principal investigators of the study for any challenges or problem that may affect the integrity and quality of the data;
  • Provide periodic reports on the quality of the laboratory process, output and outcome measures to share with local stakeholders, national and international;
  • Coordinate and manage the visits of several international experts and implement its recommendations to improve the quality of the data in the survey
  • Of the 1st National Pulmonary Tuberculosis Prevalence Survey in Mozambique (TBPS)
  • Laboratory Coordinator of the National Pulmonary Tuberculosis Prevalence Survey in Mozambique
  • National Direction of Public Health, National Tuberculosis Program Control, Ministry of Health, Eduardo Mondlane/Salvador Alende Av
  • Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038
  • Developed laboratory procedures and ensured they application during the survey implementation;
  • Coordinated and organized the activities of the survey in the mobile clinics and at the National Tuberculosis Reference Laboratory;
  • Ensured the quality and reliability of the survey data as described and approved in the study protocol;
  • Provided supervision for all laboratory personnel and developed improvements plans for successful acquirement of the survey
  • Focal Point of the National Pulmonary Tuberculosis Prevalence Survey in Mozambique
  • National Direction of Public Health, National Tuberculosis Program Control, Ministry of Health, Eduardo Mondlane/Salvador Alende Av
  • Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038
  • Manage the activities of the technical team at the INaTB laboratory;
  • Ensure the availability of laboratory consumables and reagents for processing INaTB samples;
  • Coordinate tasks for receiving samples, performing smears for smear microscopy, culture, strain speciation, Line Probe Assay (LPA) and 1st and 2nd line Drug Susceptibility Tests (TSA) using phenotypic methods;
  • Supervise and help prepare team effectiveness;
  • Preparation and presentation of activity reports;
  • Prepare monthly analysis report of quality indicators
  • Collaborate in activities related to the quality system;
  • Ensure the conservation, maintenance and cleaning of equipment and availability of materials used;
  • Propose recommendations to improve the laboratory;
  • Monitor samples according to the laboratory workflow;
  • Report results of sputum smear microscopy, culture, Line Probe Assay and drug sensitivity tests;
  • Ensure preventive maintenance of equipment
  • Coordinator of External Quality Assurance for Tuberculosis Microscopy and GeneXpert MTB/RIF

Laboratory Manager

Centro de Colaboração em Saúde
  • For the Fostering Opportunities to Respond to the TB Epidemic (FORTE), Rua Damião de Gois N
  • 279, Box 4157, Maputo, Mozambique
  • Tel.: +258 82 714 9136 Fax: +258 21 494 212
  • Focal point between the Fostering Opportunities to Respond to the TB Epidemic (FORTE) project and the Ministry of Health, USAID, and other partners in relation to the areas under its management, participate in technical and working groups and collaborate for the review of national policies and strategies, roadmaps, training materials, and other relevant documents and tools;
  • Responsible for coordinating and monitoring all laboratory area activities planned in the FORTE provinces through guidance and ongoing support to provincial laboratory officers
  • Participate in meetings and trainings in TB areas, organized/guided by FORTE/MISAU/DPS;
  • Coordinat and participate in supervisions and technical support visits with the participation of Ministry of Health and USAID
  • Ensure the fulfilment, with quality, of the requests (reports, feedback, etc.) of the Ministry of Health and USAID, respecting the established deadlines
  • Provide technical, programmatic assistance and institutional capacity building to the laboratory program at the Provincial level;
  • Provide technical, programmatic assistance and institutional capacity building to the laboratory program at the Provincial level
  • Participate in the performance evaluations of the laboratories and support the provincial officials to draw up improvement plans for the respective provinces;
  • Coordinate and support decentralization activities from External Quality Assessment (PNAEQ) programs to provincial program (PPAEQ)
  • Coordinat TB, Community Engagement and M&E Advisors to prepare periodic project reports, and promot operational research activities within TB area.

Equipment Manager, Investigator

University of Essex
  • National Tuberculosis Reference Laboratory of National Institute of Health, Eduardo Mondlane/Salvador Alende
  • AV, Postal C: 264, 3rd floor, Maputo, Mozambique
  • Tel.: +258 21431103 \ +25821311038 - Fax: +258 21431103 \ +258 21311038 http://www.ins.gov.mz
  • Develop proficiency panels for National Health System laboratories that participate in the External Quality Assessment (AEQ) for TB Microscopy and GeneXpert MTB/RIF;
  • Prepare performance reports for participants in the External Quality Assessment (AEQ)
  • Supervise the laboratory activities of the National Health System Laboratories to improve the quality of tuberculosis diagnosis in the country;
  • Provide training and technical support to technical staff of the national TB network
  • Carry out mentoring work for the implementation of the Quality Management System for regional TB reference laboratories according to the ISO 15189 standard
  • Develop study protocols in a creative and systematic way in favour of new scientific knowledge
  • Conduct research according to the protocol and following good clinical and laboratory practices
  • Participate in technical-scientific discussions (Technical-Scientific Council, Journal Club)
  • Perform Smear Microscopy techniques, GeneXpert MTB/RIF, mycobacterial culture using the conventional Lowenstein-Jensen and Ogawa-Kudoh method and automated BACTEC MGIT 960
  • Perform sensitivity tests to antibiograms (TSA) using the automated system (BACTEC MGIT 960) and molecular system (Line Probe Assay-GenoType MTBDRplus)
  • Ensure the implementation of the quality assurance system in the laboratory in accordance with ISO 15189
  • Master in Public Health (MPH) by the University of Essex, England, United Kingdom, +44 (0) 1206 489 358 or email enquiries@online.essex.ac.uk
  • Or email: admit@essex.ac.uk
  • Contemporary models and strategies to guide the design of effective health promotion activities;
  • Public health challenges of interest facing the global population;
  • Process of application of techniques for population health needs assessment;
  • Principles and methods of epidemiology with a particular focus on public health perspectives;
  • Theory and practice of key personal development skills relevant to the healthcare domain
  • Graduated in Biological Science by Eduardo Mondlane University
  • Praça 25 de Junho, Postal Code: 257 Maputo, Moçambique
  • Tel.: +258 (21) 430239, Fax: +258 (21) 304405, http://www.uem.mz
  • Biological terminology and concepts in experimental biology
  • Ability to implement a working knowledge of the scientific method and philosophy

Education

Master in Public Health (MPH) -

University of Essex
Colchester, United Kingdom
01.2023

Graduated in Biological Science -

Eduardo Mondlane University
Maputo, Mozambique
01.2012

Skills

  • TB diagnostic technologies
  • Drug susceptibility testing
  • Laboratory quality assurance
  • Data analysis techniques
  • Research protocol development
  • Technical training delivery
  • Public health strategies
  • Project coordination
  • Stakeholder engagement
  • Team leadership
  • Effective communication
  • Critical thinking
  • Attention to detail
  • Problem resolution
  • Time management
  • Sensor calibration
  • Specimen processing
  • Reagent preparation
  • Project management
  • Critical thinking proficiency
  • PCR techniques
  • Equipment maintenance
  • Biomedical device testing
  • Laboratory management
  • Laboratory work supervision
  • Laboratory safety protocols
  • Scientific writing
  • Medical laboratory procedures

Phone

+258 82 714 9136, +258 82 180 3615

Personal Information

  • Date of Birth: 08/07/85
  • Gender: Male
  • Nationality: Mozambican

References

  • Benedita José, MD, National Tuberculosis Control Program Manager, National Public Health Directorate of Ministry of Health, Mozambique, Eduardo Mondlane/ Salvador Allende Av. Nr 1008, Mozambique, +258 82 002 5907, beneditajose1@gmail.com, Currently head at Ministry of Health.
  • Ivan Manhiça, MD, MSc, Former National Tuberculosis Control Program Manager, National Public Health Directorate of Ministry of Health, Mozambique, Eduardo Mondlane/ Salvador Allende Av. Nr 1008, Mozambique, +258 82 391 7970, ivanmca2004@yahoo.com.br, Former head at Ministry of Health.
  • Khalide Azam, Ph.D., Senior Laboratory Specialist, East, Central and Southern Africa Health Community (ECSA-HC), Plot No. 157 Oloirien, Njiro Road, Arusha, Tanzania, 1009, +258 84 707 1980, Kie.azam@live.com, Former supervisor.
  • Alda Ester Chongo, MSc, Assistant Professor, Eduardo Mondlane University (UEM), Praça 25 de Junho, Maputo, Mozambique, 257, +258 82 431 1030, aestermz@gmail.com, Professor and thesis supervisor.

Studies Applied For - Degree

  • Biologist, BSc
  • Master in Public Health, MPH

Job Applied For - Position

Laboratory Manager

Timeline

Laboratory Advisor

Ministry of Health
01.2020 - Current

Laboratory Advisor

01.2012 - 01.2017

Senior Laboratory Specialist

Khalide Azam, East
01.2011 - 01.2017

Tuberculosis Control Program Manager

Benedita José, National Public Health, Public
01.2008

Assistant Professor

Alda Ester Chongo, Eduardo Mondlane University, UEM
01.2002 - 01.2015

Advisor

Curriculum Vitae

Laboratory Manager

Centro de Colaboração em Saúde

Equipment Manager, Investigator

University of Essex

Master in Public Health (MPH) -

University of Essex

Graduated in Biological Science -

Eduardo Mondlane University

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David Gabriel Macheque